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- Up to 12 hours long lasting relief with a 2 capsule dose - Specifically designed to slowly release ibuprofen - Target the source of pain by blocking the enzymes that cause pain - Helps relieves symptoms of muscular aches, strains and pains For over 30 years, Nurofen has helped to provide millions of people with pain relief. We are experienced in pain relief, and we are here to help. Nurofen contains Ibuprofen, which has anti-inflammatory properties that helps relieve the symptoms of moderate pain. Nurofen Long Lasting 300mg Capsules can be taken with water.